MOTS-c

MOTS-c is a mitochondria-derived peptide — 16 amino acids encoded within mitochondrial DNA itself, in a short open reading frame of the 12S rRNA 1. The mitochondrion doesn't only produce energy; it sends its own signals too.

It mainly targets skeletal muscle. It inhibits the folate cycle and the purine synthesis that depends on it, and that leads to AMPK activation 1 — the same energy sensor that exercise and metformin activate.

In mice, giving it prevented insulin resistance from aging and from a high-fat diet, along with diet-induced obesity itself 1.

The data are in mice, published in Cell Metabolism 1. Large clinical trials in humans haven't been done yet.

A small peptide, as sensitive as all the others. Fridge after reconstitution, keep dark, roll never shake. A research product, not a treatment.

A peptide born inside your own mitochondria — as if you already had the tool and are simply boosting it.

It targets muscle and flips the same energy switch that exercise does: AMPK 1. Like training at the molecular level.

In mouse studies, it prevented insulin resistance from aging and from a heavy diet, along with obesity itself 1.

These are mouse data, from Cell Metabolism 1 — the move to large human studies hasn't happened yet. We're keeping it honest.

Small, delicate, needs the fridge and darkness after reconstitution — roll it, don't shake it. Research first, promises later.