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PE-22-28

PE-22-28

Minimum order 2 vials or 2 pens — delivery in 2 weeks
Spadin analog and TREK-1 channel inhibitor: it inhibited TREK-1 with an IC50 of 0.12 nM (vs 40–60 nM for spadin) and reduced immobility in the forced swim test.

Category VII — Mind & Sleep 🧮 Reconstitution calculator €29 – €79 from €23.20 to €63.20

IC50 0.12 nM — PE-22-28 inhibited the TREK-1 channel far more potently than its parent spadin, with an IC50 of 40–60 nM 1.

In the forced swim test in an animal model, it reduced immobility — a marker of depressive-like behavior.

After short-term administration, neurogenesis was recorded in the same model.

What we don't know: whether this potency translates into a matching effect in humans.

Research use only, pure — nothing to do with medical treatment.

Sources — 1 published study
  1. Djillani A, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition and Antidepressant Activity. Front Pharmacol. 2017;8:643. doi:10.3389/fphar.2017.00643

0.12 nM vs 40–60 nM. PE-22-28 is far more potent at TREK-1 than spadin 1.

Less immobility in the swim test, neurogenesis afterwards. A clean finding, not bro-science.

No promises about mood in humans — we never say that.

Everything we sell is for research, purity tested.

What we don't know: action in humans. Research use only, pure.

Sources — 1 published study
  1. Djillani A, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition and Antidepressant Activity. Front Pharmacol. 2017;8:643. doi:10.3389/fphar.2017.00643

Imagine a key that opens a lock hundreds of times more easily than the old one!

PE-22-28 inhibited TREK-1 with an IC50 of 0.12 nM, vs 40–60 nM for spadin 1 — numbers that speak for themselves!

In an animal model, less immobility and more neurogenesis after short-term administration — yes, you read that right!

Purity, though? No compromises, ever.

What we don't know: humans, duration. Research use only — and we mean it!

Sources — 1 published study
  1. Djillani A, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition and Antidepressant Activity. Front Pharmacol. 2017;8:643. doi:10.3389/fphar.2017.00643

Frequently asked questions

Which packs is PE-22-28 available in?

Vial: 5 mg vial, 10 mg vial · Pens: 1 × 5 mg pen, 1 × 10 mg pen.

Is PE-22-28 in stock?

We don't keep it in stock — it's ordered in: minimum 2 items (vials or pens) from the special-order products, with free shipping, and it arrives in about 2 weeks.

How much is shipping?

€3 shipping + €3 cash-on-delivery fee. For orders of 2 vials or pens or more, shipping and the cash-on-delivery fee are free. Delivery time depends on the courier.

How do I pay?

Cash on delivery, paid to the courier when it arrives. For an electronic money transfer (PayPal, Revolut, Wise, crypto), email us for the details: ellinikapeptidia@gmail.com

Can I return it?

Yes: you have a 14-day right of withdrawal from delivery, as long as the seal is intact. Return costs are yours, unless the product was faulty or wrong. Terms of Use

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