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5-AMINO-1MQ

5-Amino-1MQ

Minimum order 2 vials or 2 pens — delivery in 2 weeks
Not a peptide — it's a small molecule that blocks the enzyme NNMT. In 24-month-old mice, muscle torque after injury was ~70% higher.

Category II — Fat Loss & Body Composition €40 – €105 from €32 to €84

It's not a peptide — it's a small organic molecule, a quinolinium derivative in salt form. More robust, easier to store, a completely different category.

It blocks the enzyme NNMT, which rises in muscle with age and pulls nicotinamide away from the NAD⁺ pathway 1. Less NAD⁺ means less sirtuin-1 activity — blocking the enzyme tries to turn that around.

In aged mice with muscle injury, an NNMT inhibitor nearly doubled muscle fiber cross-sectional area and raised peak muscle torque by about 70% 1. In obese mice, together with a low-fat diet, it brought body composition back to the levels of animals that had always eaten low-fat 2.

All the data are in mice, and the studies talk about the class “NNMT inhibitor” without naming the molecule itself 12. Fair to say the class showed it — not that this exact molecule did.

As a small-molecule salt it's more robust in storage than the peptides next to it, but it's hygroscopic — sealed, dry, away from moisture. Research first, glow later.

Sources — 2 published studies
  1. Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. doi:10.1016/j.bcp.2019.02.008
  2. Sampson CM, Dimet AL, Neelakantan H, et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci Rep. 2021;11(1):5637. doi:10.1038/s41598-021-85051-6

Not even a peptide — a small organic molecule in salt form. Different category, different storage, the same seriousness about the data.

It blocks NNMT, the enzyme that climbs in muscle over the years and steals nicotinamide from the NAD⁺ pathway 1. Less NAD⁺, less sirtuin-1 — that's what it tries to reverse.

In aged mice with muscle injury, an NNMT inhibitor nearly doubled muscle fiber cross-sectional area and raised peak torque about 70% above control animals 1. In obese mice, together with a low-fat diet — not instead of it — it accelerated fat loss 2.

Straight talk: all in mice, no human studies. And both studies talk about “an NNMT inhibitor” as a class, without naming the molecule in their abstracts 12.

More robust than the peptides, doesn't need the same cold-chain care — but it's hygroscopic, so keep it sealed and dry. Research, not a guarantee.

Sources — 2 published studies
  1. Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. doi:10.1016/j.bcp.2019.02.008
  2. Sampson CM, Dimet AL, Neelakantan H, et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci Rep. 2021;11(1):5637. doi:10.1038/s41598-021-85051-6

First, the most basic point: this is not a peptide.

Everything else in this catalog is a chain of amino acids. 5-amino-1MQ is a small organic molecule — a quinolinium derivative, in salt form. We put this first because it changes everything: how it's stored, how it's taken, how it behaves.

What it blocks. The enzyme NNMT (nicotinamide N-methyltransferase). This enzyme is overexpressed in skeletal muscle with aging, and when it works overtime it pulls nicotinamide away from the NAD⁺ salvage pathway 1. Less NAD⁺ also means less sirtuin-1 activity. Blocking the enzyme is an attempt to turn that around.

The numbers — and they're impressive. 24-month-old mice — that is, aged — with an induced injury to the tibialis anterior. With an NNMT inhibitor: proliferation of muscle stem cells, muscle fiber cross-sectional area nearly doubled, and — most importantly, because it's functional rather than histological — peak muscle torque about 70% higher than in control animals 1.

And in a second study, in diet-induced obese mice: an NNMT inhibitor together with a switch to a low-fat diet accelerated fat loss and brought body composition and liver fat back to the levels of age-matched control animals that had always eaten low-fat 2. Note the wording: together with the diet, not instead of it.

And the two “buts,” side by side. First and biggest: it's all in mice. No human studies. Second, subtler but essential: the studies talk about “an NNMT inhibitor” — the class 5-amino-1MQ belongs to — without naming the molecule in their abstracts 12. It's fair to say the class showed these results. It's not fair to say this exact molecule did.

Sources — 2 published studies
  1. Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. doi:10.1016/j.bcp.2019.02.008
  2. Sampson CM, Dimet AL, Neelakantan H, et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Sci Rep. 2021;11(1):5637. doi:10.1038/s41598-021-85051-6

Both studies are in mice, and they concern the class “NNMT inhibitor,” not 5-amino-1MQ by name.

Frequently asked questions

Which packs is 5-Amino-1MQ available in?

Pack: 10 mg, 50 mg · Pens: 1 × 10 mg pen, 1 × 50 mg pen.

Is 5-Amino-1MQ in stock?

We don't keep it in stock — it's ordered in: minimum 2 items (vials or pens) from the special-order products, with free shipping, and it arrives in about 2 weeks.

How much is shipping?

€3 shipping + €3 cash-on-delivery fee. For orders of 2 vials or pens or more, shipping and the cash-on-delivery fee are free. Delivery time depends on the courier.

How do I pay?

Cash on delivery, paid to the courier when it arrives. For an electronic money transfer (PayPal, Revolut, Wise, crypto), email us for the details: ellinikapeptidia@gmail.com

Can I return it?

Yes: you have a 14-day right of withdrawal from delivery, as long as the seal is intact. Return costs are yours, unless the product was faulty or wrong. Terms of Use

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