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AOD-9604

AOD-9604

Minimum order 2 vials or 2 pens — delivery in 2 weeks
Fragment 176-191 of growth hormone. It burned fat in obese mice without raising blood sugar — because it doesn't even bind the growth hormone receptor.

The tail of growth hormone — the fat-burning piece, without the rest of its baggage.

The idea was elegant: if the fat-burning part is just the tail of growth hormone, cut off the tail and keep only that. AOD-9604 is exactly that — amino acids 176 to 191.

The number: in obese mice, 14 days of continuous dosing, AOD-9604 significantly reduced weight gain, with increased fat oxidation and increased plasma glycerol — in other words, real lipolysis 1.

And the most beautiful part: it doesn't carry growth hormone's side effects — it didn't raise blood sugar, it didn't lower insulin 1. But honesty has its place: all of this is mouse data, and two decades on it remains a research compound, approved for obesity nowhere.

It's a design story, not yet a clinical success story — and we'd rather tell it to you that way.

A hexadecapeptide with a disulfide bond, sensitive to shaking. Swirl, chill, keep dark — strictly for research use.

Sources — 1 published study
  1. Heffernan MA, Thorburn AW, Fam B, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-1449. doi:10.1038/sj.ijo.0801740

Growth hormone, trimmed on purpose — you keep only the piece that works on fat.

AOD-9604 is amino acids 176-191 of growth hormone — the tail, without the rest of the molecule.

The numbers: in obese mice, 14 days of continuous dosing, it significantly reduced weight gain with increased fat oxidation and plasma glycerol — real lipolysis 1. And it doesn't compete for the growth hormone receptor — it didn't raise blood sugar, didn't drop insulin 1, and doesn't affect the WADA doping test 2.

Straight talk: all of the above is in mice. It entered phase II clinical trials for obesity in the early 2000s 3, but two decades later it isn't approved anywhere for that use.

You know what it does and what it hasn't proven yet — that's more useful than a promise.

A hexadecapeptide with a disulfide bond — the bond breaks with shaking. Swirl, chill, keep dark.

Sources — 3 published studies
  1. Heffernan MA, Thorburn AW, Fam B, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-1449. doi:10.1038/sj.ijo.0801740
  2. Orlovius AK, Thomas A, Schänzer W, Thevis M. AOD-9604 does not influence the WADA hGH isoform immunoassay. Drug Test Anal. 2013;5(11-12):850-852. doi:10.1002/dta.1557
  3. Wilding J. AOD-9604 Metabolic. Curr Opin Investig Drugs. 2004;5(4):436-440. PMID:15134286

The tip of growth hormone, cut off on purpose.

The idea was ambitious: growth hormone burns fat, but it brings everything else along with it — it raises blood sugar, messes with insulin, makes cells multiply. If the fat-burning part is just its tail, then you cut off the tail and keep only that. AOD-9604 is that tail: amino acids 176 to 191.

And it worked — in mice. Obese and lean mice, 14 days of continuous dosing via osmotic pumps. Both growth hormone and AOD-9604 significantly reduced weight gain, with increased fat oxidation and increased plasma glycerol — in other words, real lipolysis 1.

And here's the interesting half. Unlike growth hormone, AOD-9604 didn't cause hyperglycemia and didn't reduce insulin secretion. The reason turned up in the same experiment: it doesn't even compete for the growth hormone receptor, and it doesn't cause cell proliferation 1. Thirteen years later the same thing was confirmed from another angle: it has no effect at all on the WADA doping test for growth hormone 2. The body simply doesn't see it as growth hormone.

That's the good news and the bad news at once. Good: it doesn't bring growth hormone's baggage. Bad: it doesn't do any of what growth hormone does either.

And now the timeline. AOD-9604 entered phase II clinical trials for obesity in the early 2000s 3, and was still listed as in development in 2006 4. Two decades on, it isn't an approved obesity drug anywhere. We're not telling you why — we don't know. We're telling you it didn't make it.

Sources — 4 published studies
  1. Heffernan MA, Thorburn AW, Fam B, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-1449. doi:10.1038/sj.ijo.0801740
  2. Orlovius AK, Thomas A, Schänzer W, Thevis M. AOD-9604 does not influence the WADA hGH isoform immunoassay. Drug Test Anal. 2013;5(11-12):850-852. doi:10.1002/dta.1557
  3. Wilding J. AOD-9604 Metabolic. Curr Opin Investig Drugs. 2004;5(4):436-440. PMID:15134286
  4. Jensen MD. Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors. Obesity (Silver Spring). 2006;14 Suppl 3:143S-149S. doi:10.1038/oby.2006.294

1 is in mice. There's no published randomized human study with a positive result on weight.

Frequently asked questions

Which packs is AOD-9604 available in?

Vial: 5 mg vial · Pens: 1 × 5 mg pen.

Is AOD-9604 in stock?

We don't keep it in stock — it's ordered in: minimum 2 items (vials or pens) from the special-order products, with free shipping, and it arrives in about 2 weeks.

How much is shipping?

€3 shipping + €3 cash-on-delivery fee. For orders of 2 vials or pens or more, shipping and the cash-on-delivery fee are free. Delivery time depends on the courier.

How do I pay?

Cash on delivery, paid to the courier when it arrives. For an electronic money transfer (PayPal, Revolut, Wise, crypto), email us for the details: ellinikapeptidia@gmail.com

Can I return it?

Yes: you have a 14-day right of withdrawal from delivery, as long as the seal is intact. Return costs are yours, unless the product was faulty or wrong. Terms of Use

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