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SEMAX

Semax

Minimum order 2 vials or 2 pens — delivery in 2 weeks
A piece of ACTH — amino acids 4 to 10 — without the hormonal action. In 52 healthy volunteers, fMRI showed it changed right amygdala connectivity within 20 minutes.

Category VII — Mind & Sleep 🧮 Reconstitution calculator €33 – €127 from €26.40 to €101.60

Semax is a cut-off piece of ACTH — the hormone that tells the adrenal glands to release cortisol — but without the part that talks to the adrenals.

Only the 4-10 fragment (MEHFPGP) remains, with a Pro-Gly-Pro tail for stability. The literature describes it as an analog with nootropic and neuroprotective activity 1.

In a study of 52 healthy volunteers with placebo, functional MRI detected changes in connectivity between the right amygdala and the right temporal cortex just 5 and 20 minutes after injection 2.

This shows the molecule reaches the brain and does something measurable, fast — not that it improves memory or focus, because those weren't measured 2. And its literature comes mainly from one research circle, without broad independent replication.

Research-use product. It's also available in a more stable form (NA-Semax); plain Semax needs refrigeration, darkness and rolling instead of shaking.

Sources — 2 published studies
  1. Glazova NYu, Manchenko DM, Volodina MA, et al. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides. 2020;86:102114. doi:10.1016/j.npep.2020.102114
  2. Panikratova YaR, Lebedeva IS, Sokolov OYu, et al. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020;490(1):9-11. doi:10.1134/S001249662001007X

It's not a muscle peptide. It works in your head, and the data show it — literally, in an image.

It's an ACTH fragment without the part that activates the adrenals — only the central nervous system action remains, nootropic and neuroprotective according to the literature 1.

In a study of 52 healthy people, functional MRI showed changes in brain connectivity just 5 and 20 minutes after injection 2.

Straight talk: they measured brain signal, not performance, memory or focus. One doesn't guarantee the other. And the literature comes mainly from one research circle in Moscow.

Research-use product. Refrigerate, keep dark, roll — never shake. The N-acetylated form (NA-Semax) is the more stable one to handle.

Sources — 2 published studies
  1. Glazova NYu, Manchenko DM, Volodina MA, et al. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides. 2020;86:102114. doi:10.1016/j.npep.2020.102114
  2. Panikratova YaR, Lebedeva IS, Sokolov OYu, et al. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020;490(1):9-11. doi:10.1134/S001249662001007X

A cut-off piece of a hormone, without the hormone.

ACTH is the hormone that tells the adrenal glands to release cortisol. Semax is its 4-10 fragment (MEHFPGP) with a Pro-Gly-Pro tail attached to the end. The part that talks to the adrenals isn't in it: only the action on the central nervous system remains. The literature describes it as a synthetic ACTH(4-10) analog with nootropic and neuroprotective activity 2.

What was measured in humans. 52 healthy participants, with placebo. Resting-state functional MRI three times: before, 5 minutes and 20 minutes after the injection. Differences were found in functional connectivity between the right amygdala and an area of the right temporal cortex — and the analysis separated, for the first time, what Semax does from what Selank does 1.

What this means — and what it doesn't. It means the molecule reaches the brain and does something measurable, fast. It does not mean you'll study better: nobody in this study measured memory, focus or performance. It measured signal.

And the important part you'll rarely see written down. Semax has been marketed in Russia as an approved drug for decades, and almost all of its literature — including the study you just read about — comes from one circle of researchers in Moscow. That doesn't mean it's wrong. It means it hasn't been independently replicated by three labs in three countries, and that's a different thing.

Sources — 2 published studies
  1. Panikratova YaR, Lebedeva IS, Sokolov OYu, et al. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020;490(1):9-11. doi:10.1134/S001249662001007X
  2. Glazova NYu, Manchenko DM, Volodina MA, et al. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides. 2020;86:102114. doi:10.1016/j.npep.2020.102114

2 is a study in rats. 1 is in humans, but it measures brain signal — not performance.

Frequently asked questions

Which packs is Semax available in?

Vial: 5 mg vial, 10 mg vial, 30 mg vial · Pens: 1 × 5 mg pen, 1 × 10 mg pen, 1 × 30 mg pen.

Is Semax in stock?

We don't keep it in stock — it's ordered in: minimum 2 items (vials or pens) from the special-order products, with free shipping, and it arrives in about 2 weeks.

How much is shipping?

€3 shipping + €3 cash-on-delivery fee. For orders of 2 vials or pens or more, shipping and the cash-on-delivery fee are free. Delivery time depends on the courier.

How do I pay?

Cash on delivery, paid to the courier when it arrives. For an electronic money transfer (PayPal, Revolut, Wise, crypto), email us for the details: ellinikapeptidia@gmail.com

Can I return it?

Yes: you have a 14-day right of withdrawal from delivery, as long as the seal is intact. Return costs are yours, unless the product was faulty or wrong. Terms of Use

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